Senior Scientist or Scientist - Drug Metabolism and Pharmacokinetics (DMPK)

Position Summary

We are seeking a highly motivated, hands-on scientist to join our academically-oriented team supporting primarily small-molecule drug discovery and development. This laboratory-based role requires direct execution of bioanalytical, in vitro DMPK, and in vivo PK studies. The successful candidate will have a track record of executing such work directly rather than managing or outsourcing it. This is a bench-focused position emphasizing practical, experimental work across a DMPK-style workflow in an academic, non-profit environment.

Key Responsibilities:

• Perform quantitative LC-MS/MS bioanalysis of small and/or large molecules in biological matrices (plasma, tissues, etc.) from in vitro and in vivo studies to support PK/PD, ADME, and efficacy evaluations (experience with SCIEX instrumentation preferred; non-regulated/discovery BA setting is acceptable).
• Execute in vitro DMPK assays, including plasma protein binding, microsomal stability incubations, hepatocyte metabolism studies, and permeability assessments in cell monolayers.
• Conduct in vivo PK studies, dosing by various standard routes, terminal and non-terminal blood sampling, and organ/tissue collection.
• Develop and/or prepare preclinical formulations by dissolving or suspending test agents for in vivo dosing.
• Analyze data, maintain accurate records (LIMS, lab notebooks, reports), and communicate results to the Director and project team in a fast-paced environment.
• Performs other related duties as assigned in order to meet the goals of the department and institution.
• Maintains regular and predictable attendance.

Minimum Qualifications:

• Demonstrated experience with LC-MS/MS bioanalysis for small molecules.
• Practical laboratory experience running in vitro DMPK/ADME assays (protein binding, microsomes, hepatocytes, monolayers).
• Direct hands-on experience executing in vivo PK studies (dosing, sampling, tissue collection).
• Working knowledge of preclinical formulation techniques (solutions and suspensions).
• Strong attention to detail, organizational skills, and ability to plan and work independently while collaborating effectively.

Minimum Education and/or Training:

• Bachelor's degree in Chemistry, Biology, Pharmacology, Pharmaceutical Sciences, or related discipline is required.

Scientist Minimum Experience:

• Eight (8) years of relevant work experience is required.
• Six (6) years of relevant work experience is required with a Master's degree.
• Three (3) years of relevant work experience is required with a PhD.

Scientist Salary Range: $86,320.00 - $154,960.00

Senior Scientist Minimum Experience:

• Ten (10) years relevant work experience is required.
• Eight (8) years of relevant work experience is required with a Master's degree.
• Five (5) years of relevant work experience is required with a PhD.

Senior Scientist Salary Range: $104,000.00 - $186,160.00

Compensation

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St. Jude is an Equal Opportunity Employer

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