Immunology Principal Research Associate

Job Description

General Summary:

The discovery immunology research team is seeking a highly motivated Principal Research Associate. This is a laboratory-based role where the successful candidate will contribute directly to research efforts by designing, executing, and analyzing experiments related to immune mechanisms, target validation, and therapeutic development. The position requires strong attention to detail and ability to multitask while working in a highly collaborative environment.

Key Duties and Responsibilities:

• Isolate, culture, and manipulate primary human immune cells and cell lines.

• Design and execute experiments to interrogate immune cell phenotype and function, including cell-based multicolor flow cytometry and Incucyte assays.

• Troubleshoot experiments and optimize protocols.

• Collect, analyze, and interpret experimental data while maintaining accurate and detailed laboratory records.

• Collaborate with scientists across discovery teams to achieve project goals.

• Prepare data for internal reports and presentations for internal meetings.

• Perform other duties as needed.

Knowledge and Skills:

• Hands-on tissue culture experience, including the isolation and maintenance of primary human immune cells and human cell lines.

• Experience with nucleic acid techniques to quantify gene expression such as PCR, qPCR, and RNA sequencing.

• Experience with a variety of cell-based immunology assays to interrogate immune cell phenotype and function including multicolor flow cytometry and Incucyte assays.

• Experience measuring soluble analytes such as by ELISA, Luminex, or MSD.

• Critical thinking and self-reliance to solve tasks independently or ask questions.

• Strong organizational skills and attention to detail.

• Willingness and ability to work in a highly collaborative environment.

• Foundational knowledge of immunology and an eagerness to learn new techniques and skills.

• Strong analytical skills and proficiency in the following software packages: Microsoft Office, GraphPad Prism, FlowJo and Methodical Mind Analysis Software.

Education and Experience:

• Master's degree (or equivalent degree) in biological sciences and 2+ years of relevant employment experience, or

• Bachelor's Degree (or equivalent degree) in biological sciences and 5+ years of relevantemployment experience

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com