Principal Scientist, Organoid Technologies

We are seeking a highly motivated, enthusiastic and skilled cell biologist to join our group within the Human Biology department at our US Research Hub. This laboratory-based role is critical to advancing our early discovery efforts through the development and application of physiologically relevant in vitro models that mimic complex disease biology. The successful candidate will leverage cutting-edge technologies, including primary human cells, 3D cell culture, gene editing, and functional genomics, to drive target discovery and validation efforts in areas of high unmet medical need. Working in a multidisciplinary and collaborative environment, you will generate impactful insights that inform and accelerate therapeutic discovery and development.

• Laboratory-based role
• Lead the design and execution of experiments involving primary human cells and patient-derived organoids to support early target discovery, validation and mechanistic studies.
• Apply CRISPR-based gene editing, molecular biology, and imaging techniques to interrogate gene function in disease contexts.
• Translate biological insights into clinically actionable therapeutic strategies, aligned with disease-relevant endpoints.
• Collaborate cross-functionally with internal partners in human genetics, computational biology, AI/ML, automation, and disease areas.
• Maintain excellent experimental records according to GSK compliance.
• Communicate experimental findings effectively (in written and verbal formats) in internal and external scientific forums

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• PhD in Cell Biology, Bioengineering or related life sciences field with 3+ years of research experience in a postdoctoral or industry setting
• Publications in peer reviewed journals
• 3+ Years of hands-on experience in basic molecular and cellular techniques (e.g., molecular cloning, immune-staining, flow cytometry, cell culture).
• Hands-on experience with advanced cellular models such as primary cell cultures, patient-derived organoids, co-cultures, and 3D cell systems

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Deep knowledge of oncology and tumor microenvironment modeling.

• Familiarity with functional genomics, transcriptomics, proteomics, and/or high-content imaging technologies.

• Self-motivated with an insatiable appetite for learning.

• Embodies a positive-mindset and team mentality.

• Quick learner who is driven to deliver impact.

• Strong scientific leadership as well as excellent written and oral communication.

#LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

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GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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