Principal Associate Scientist, Research

The Research Department at Alnylam is seeking a passionate and enthusiastic Principal Associate Scientist to join our interdisciplinary team focused on advancing extrahepatic siRNA delivery and our mechanistic understanding of RNAi biology across tissues, specifically skeletal muscle, heart, and kidney. The role requires a strong background in biological sciences and technical skillsets in in vitro cell culture as well as molecular and biochemical assays. Prior experience or a willingness to learn in vivo rodent work is strongly preferred. We seek someone who will flourish in a goal- and timeline-oriented collaborative environment and be able to rapidly learn new topics and experimental techniques.

This position islab-based onsiteand will be primarily located in Cambridge, MA.

Key Responsibilities

• The candidate will engage in a variety of mechanistic siRNA research efforts to evaluate RNAi compounds, utilizing biochemical, molecular, and cell-based assays.
• Design, execution, interpretation, and troubleshooting of experiments on an individual basis as well as part of a collaborative team.
• Presentation of results in both written and oral format to key stakeholders within the Research organization.

Qualifications

• BS/MS in Biology, Biochemistry, or related field with 6+ (BS) or 4+ (MS) years of work experience, preferably in industry setting
• Prior experience and/or working knowledge of nucleic acid-based therapies (siRNA, ASO, CRISPR) is highly desired.
• Proficiency in mammalian immortalized and primary cell culture (maintenance, transfection/stable selection).
• Molecular biology assays to support evaluation of siRNA activity (qPCR, Western blotting, ELISA, Ago-immunoprecipitation, etc.).
• Experience with (or willingness to learn) in vivo rodent handling and experimentation is a plus.
• Excellent lab technique and ability to work independently.
• Strong interpersonal skills and excellent communication skills (written and oral) are required.

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.