Description
Under the supervision of the Manufacturing Manager of the
Human Gene and Cell Therapy Facility (HGCTF), the HGCTF Lead Manufacturing
Associate is responsible for the manufacturing of human gene and cell therapy
products under Good Manufacturing Practices (GMP), quality control testing of
these products to ensure that the products meet the required quality, supervise
other manufacturing associates and overall management of all projects. The
purpose of the HGCTF is to manufacture clinical grade gene and cellular therapy
products for novel patient treatments in clinical trials, and to perform
scholarly research and development when appropriate. These objectives are to be
met within the limits of resources available with an emphasis on cost
effectiveness and innovation. The ideal candidate must have excellent tissue culture
skills (human cell line and stem cell culture preferred), be trained in GMP
grade culture and formulation of various human cell types including peripheral
blood mononuclear cells, T-cells, dendritic cells, multi potent stem cells such
as mesenchymal stromal cells, pluripotent stem cells, such as human embryonic
stem cells and induced pluripotent stem cells, project and personnel management
skills and experience in quality control tests. Annual Salary Range: $83,800 - $179,400
Qualifications
All Required:
- Bachelor of Science or Master
of Science or Ph.D. Degree in Biology, Chemistry, or related field, or
equivalent experienceand a minimum of 2 years of manufacturing experience
in GMP setting.
Knowledge and practical
experience in aseptic technique/tissue culture.
Understanding of GMP
requirements and regulations. Previous experience directly involved with
federal regulations regarding GLP and GMP.
Knowledge of Standard
Operating Procedures and Quality Control requirements in a GMP laboratory
setting.
Work independently, with
emphasis on the ability to closely follow SOPs.
Ability to wear protective
clothing for extended periods of time including: gowns, coveralls, gloves,
masks, face shields, goggles, sleeves and head covers.
Ability to work flexible
hours, various hours on short notice (including covering staff shortages and
holiday shifts); determine workload priorities for completion of job
assignments in a timely manner to meet critical deadlines
Ability to serve as a resource
for complex procedure or equipment troubleshooting in areas of expertise,
and/or solicits same as necessary in areas where expertise is deficient.
Strong interpersonal
communication skills to effectively and diplomatically interact with
physicians, staff, administration & sponsors.
Advanced knowledge of cell
culture, cell line development, bioreactor operation and scale-up,
centrifugation and ultracentrifugation, tangential flow and normal flow
filtration
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University of California - Los Angeles Health
May 27, 2025