New

Principal Scientist I, In Vivo Pharmacology (Echocardiography) - CVM

Novartis Group Companies
parental leave, paid time off, sick time, 401(k)
United States, Massachusetts, Cambridge
May 24, 2025
Job Description Summary We are seeking a highly motivated scientist with expertise in echocardiography to join our in vivo pharmacology team in the Cardiovascular and Metabolic (CVM) Disease Area at the Novartis BioMedical Research (BR) facility in Cambridge, MA. Cardiometabolic disease is the leading cause of death globally, claiming approximately 17.9 million lives annually. Our team is committed to developing innovative medicines to address this critical health issue. We design, develop, validate, and utilize pharmacological tools to assess the efficacy and safety of new cardiometabolic drug candidates. As an experienced and skilled lab-based echocardiographer, you will work both independently and collaboratively in an interdisciplinary setting to conduct experiments in preclinical models of cardiovascular disease. You will perform multi-mode echocardiography, including strain by speckle tracking and Doppler imaging, to assess heart systolic and diastolic function. You will collect, analyze, and interpret echo images, and report cardiac structural and functional data in both written study reports and team meetings. You will support drug discovery for heart failure and arrhythmia therapeutics by participating in pharmacodynamic/pharmacokinetic (PK/PD) and efficacy studies, while expanding your knowledge in the field of non-invasive imaging. #LI-Onsite This position will be located at Cambridge, MA and will not have the ability to be located remotely. Job Description Key Responsibilities: Independently design, execute, analyze, and document in vivo echocardiographic experiments in heart failure and/or arrhythmia animal models. Actively mentor, train, and support the career development of direct reports, matrix direct reports, or junior associates. Leverage extensive, current knowledge of heart failure and arrhythmia indications to initiate, influence and/or drive projects. Identify scientific and technical trends in the field that influence project outcomes. Utilize comprehensive knowledge of project and drug discovery processes to formulate and address key scientific and technical questions. Establish new imaging techniques and approaches to support heart failure or arrhythmia studies. Adhere to good laboratory practices, including meticulous data recording and documentation. Contribute to drug discovery projects by conducting PK/PD studies. Work collaboratively and efficiently within a matrixed environment. Role Requirements: Master's Degree plus 3 years of experience or recently completed PhD in Pharmacology or related life sciences preferred. Experience in conducting echocardiography in preclinical animal models of heart failure and arrhythmia. Experience in MRI is a plus. Proven expertise in experimental design and execution. Experience in working with a multidisciplinary team of scientists. Sound understanding of statistics and experience with common statistical software for biomedical research. Strong written, oral and record keeping skills. Our Expectations: An ability to work both independently and as part of a team Flexibility and aptitude for learning, with a passion to drive groundbreaking science Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $103,600 and $192,400/year; however, while salary ranges are effective from 1/1/25 through 12/31/25, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $103,600.00 - $192,400.00 Skills Desired Analytical Skill, Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Communication Skills, Curiosity, Data, Data Analysis, Design Of Experiments, Detail-Oriented, Drug Development, Drug Discovery, Ethics, Gene Therapy, Immunology, Inventory Management, Laboratory, Lifesciences, Machine Learning (Ml), Management, Medical Research, Molecular Biology {+ 10 more}