Vice President, Center for Translational Genomics and Proteomics, Genentech Research and Early Development (gRED)

Vice President, Center for Translational Genomics and Proteomics

Genentech Research and Early Development (gRED)

The new Center for Translational Genomics and Proteomics will integrate cutting-edge efforts in cell and tissue genomic technology, proteomics and genomics technologies, human genetics and functional genomics under one organization to advance our Mission to discover and develop transformative therapies. The Center will investigate key biological questions at an unprecedented scale enabled by unparalleled lab and AI capabilities in gRED to enable the training of foundation models for target and drug discovery and to help discover novel targets and develop clinical candidates in collaboration with all of our therapeutic areas. The leader will craft and implement a strategic vision for the Center. They will also foster an innovative and collaborative environment of technical and biological excellence and creativity in the Center and across gRED to shape and complement existing target discovery efforts.

Functional role and key accountabilities:

Genentech works across five major therapeutic areas - oncology, immunology, neuroscience, ophthalmology, and cardiovascular and metabolic disease, along with dedicated research in infectious disease. TheHead of Translational Genomics and Proteomics will oversee an organization of ~130 researchers and leaders, encompassing the Departments of Cell and Tissue Genomics, Proteomics and Genomics Technologies, Human Genetics and Functional Genomics. The Center works in collaboration with groups across Genentech and Roche on discovery and delivery of new portfolio targets from functional and translational genomics efforts through interrogation of healthy and human disease tissues and functional screens in diverse cell, organoid and animal models. The Center develops and adapts next-generation massively parallel, high resolution technologies compatible with iterative lab-in-a-loop experiments, and collaborates with gRED Computational Sciences (gCS) to generate foundational datasets to train foundation models for target and drug discovery. They also assess and develop external partnerships to complement internal efforts. The Head of the Center will report to SVP, Research-Biology in gRED, an independent R&D division in the Roche group. Given the importance of linking our discovery efforts with clinical research, the head of the Center will also have a dotted line reporting to the SVP, Translational Medicine in gRED.

The leader's key accountabilities include:

• Creating and implementing, in collaboration with leaders across gRED, Genentech and Roche, a strategy for translational genomics for the broad therapeutic needs of the organization.

• Build, develop and lead an umbrella organization to foster a community for novel target discovery.

• Lead and develop cutting edge core technologies in genomics and proteomics to advance and support the Research and Development portfolio.

• Collaborate with functions across gRED, Genentech and Roche to ensure a seamless target discovery and drug development pipeline.

• Collaborate closely with Drug Discovery to deploy its capabilities in phenotypic screens for hit generation and assessment of mechanisms of action throughout the drug discovery and development phases.

• Collaborate closely with gCS on the development of lab-in-the-loop experiments and collection of datasets for training foundation models that drive target and drug discovery.

• Work in close collaboration with the VP of Translational Medicine and the TM Leadership Team on biomarker and translational research projects, including both analysis of clinical samples as well as pre-clinical translational experiments. TM collaborative projects will include biomarker discovery, evaluation of novel biomarkers in clinical samples, discovering new disease endotypes, studying mechanisms of response and resistance, novel target discovery ("reverse translation"), and other translational research projects.

• Be a thought leader in large-scale research of disease biology, target discovery and drug discovery.

• Seek, foster and maintain external partnerships that add value, create flexibility, access expertise and drive return for gRED.

• Nominating programs for target assessment and research portfolio entry.

• Accountable for contributing to target identification, and ultimately, enhanced portfolio productivity.

• Partner across Genentech and Roche to collaborate on high priority shared goals.

• Seamless coordination with VPs of each therapeutic research area, SVP of Translational Medicine, SVP of Drug Discovery, SVP of Development Sciences, SVP of gRED Computational Sciences (gCS) and VP of Computational Biology and Translation, gCS.

• Member of the Research Review Committee.

• Member of the Research Leadership Team.

• Contribute to appropriate governance bodies to establish strategic directions and deliver critical objectives across the entire organization to improve efficiency and accelerate product development.

Qualifications and Experience:

• PhD, MD, MD / PhD or equivalent advanced degree.

• Proven leader with ideally 10+ years of experience, including at least 5 years as a laboratory or institute head, Director level or above, and/or industry experience in coordinating multi-discipline functions.

• Outstanding track record of scientific accomplishments spanning the field as demonstrated through scientific publications, presentations and/or patents.

• Specific demonstrated ability to bridge large scale experimental technologies with computational approaches to drive biological insights

• Critical thinker with ability to analyze possibilities, solutions, and development of pragmatic solutions, as well as a "big picture" innovator.

• Strong, lucid and influential communicator: exceptional influencing skills that demonstrate strong thought partnership and create effective relationships with internal and external stakeholders.

• Excellent collaboration skills and ability to build and connect strong teams and communities.

• Record of developing and mentoring excellent scientific leaders.

This position is eligible for relocation benefits.

The expected salary range for this position based on the primary location of California is $392,275.00 and $484,575.00. Actual pay will be determined based on experience, qualifications and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance, as well as participation in a long-term incentive program. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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