Postdoctoral Research Fellow

Massachusetts General Hospital
United States, Massachusetts, Boston
60 Blossom Street (Show on map)
Mar 20, 2025
If interested in the position, please email a cover letter, CV, and three references to Dr. Haobo Li (email: haobo.li@mgh.harvard.edu). GENERAL SUMMARY/ OVERVIEW STATEMENT: The laboratory of Dr. Haobo Li within the Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital is seeking a post-doctoral research fellow with training in molecular biology and small animal work, preferably in the context of cardiovascular and/or aging research. The lab is located on the Boston campus of the MGH Department of Anesthesia (Edwards Research Building). The laboratory investigates mechanisms that drive aging and vascular/heart disease as well as cerebral disease, through genetic, pharmacological, and physiological (i.e. exercise) interventions. The selected candidate will join an extraordinary group of talented and motivated basic and clinical scientists whose work has direct translational applications and is linked to potential novel therapeutics. Additionally, he/she will be fully integrated into the outstanding biomedical research environment at MGH and Harvard Medical School, and participate in active collaborations with the Broad Institute, MIT, and the Boston Pepper Center. The candidate will be mentored by Dr. Haobo Li, PhD and fully supported by NIH fundings. The specific projects he/she will be working on will be focused on investigating fundamental mechanisms of biological aging that contribute to frailty and cardiovascular disease and cerebral disease. The projects will largely build off the lab's recent publications (Li et al, Circulation, 2022; Li et al, Circulation Research, 2020; Kang et al, AJP-Heart, 2024), which identified long noncoding RNAs and age-related biological pathways involved in cardiac aging, frailty, and heart failure. Scientific investigations will include work in both human biospecimens and preclinical animal and cell culture models. Extensive training in advanced molecular biology techniques, high throughput transcriptomic and proteomic screening, viral vectors, transgenic models, exercise and cardiac physiology (echocardiography, exercise testing, etc), and small animal heart failure models (pharmacological and surgical interventions) will be acquired during this fellowship period. PRINCIPAL DUTIES AND RESPONSIBILITIES: With supervision and guidance, responsibilities of the Postdoctoral Research Fellow will include: Performs independent and highly specialized experimental procedures Designs and implements modifications of research protocols Troubleshooting problems and instructing colleagues in highly specialized techniques Synthesizes and interprets results Performs advanced data recording and analysis using various software programs and statistical techniques Maintaining organized and detailed records of laboratory experiments in electronic laboratory notebooks Presentation of results at lab meetings and national conferences Preparation and submission of research manuscripts to peer-reviewed journals Assisting with preparation of grant applications Other duties as assigned EXPERIENCE: Prior lab experience required. Must have evidence of strong scientific productivity, including peer-reviewed publications. Open to highly motivated candidates with a relevant background. EDUCATION: A PhD in a basic science discipline is required, as well as a minimum two-year commitment. SKILLS/ABILITIES/COMPETENCIES REQUIRED: A successful candidate will: Work independently under general direction of the Principal Investigator Be motivated, meticulous, organized, and detail-oriented Demonstrate initiative and enthusiasm for learning new techniques Have strong analytical and problem-solving skills Possess strong technical abilities and computer science skills Possess exceptional written and oral communication skills as demonstrated by publications and presentation Possess the ability to make independent and effective decisions in a timely fashion Possess competence in research techniques and methodologies Have excellent interpersonal skills Be a team player who works well with other lab members SUPERVISORY RESPONSIBILITY (if applicable): Assistance guiding research technicians and trainees in the lab is expected. WORKING CONDITIONS: Work will be performed in a fast-paced research laboratory environment, requiring teamwork, collaboration, and flexibility. Must be able to work independently. If interested in the position, please email a cover letter, CV, and three references to Dr. Haobo Li (email: haobo.li@mgh.harvard.edu). The General Hospital Corporation is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.