Scientist, Neuroimmunology

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

Neurocrine Biosciencesis a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visitneurocrine.com, and follow the company onLinkedIn,XandFacebook. (*in collaboration with AbbVie)

About the Role:

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• Performs assigned experiments that support scientific activities and project goals, in vitro and in vivo

• Collaborates with team members to develop and validate in vitro assays and in vivo animal disease models

• Conduct research innovatively with independent ideas and approaches to answer team's biology questions and solve issues

• Experienced therapeutic Ab discovery

• Responsible for developing in vivo animal disease models including autoimmune diseases and neurodegenerative disease models

• High skills of animal handling, drug dosing and surgery of various tissues from disease model and

• High skills of cellular assay including cell line, primary cells from human and rodents, ex vivo assay from animal models

• Understand and perform flow cytometry assay and immune cell function assay including isolating primary immune cells, cytokine assays, cell differentiation and functional assays, ligand-mediated signal transduction etc.

• Design and execute in vivo animal autoimmune disease models to study disease progression, evaluate therapeutic interventions, and uncover molecular mechanisms of action. Provide drug candidate efficacy and mechanism of action to support drug candidate selection and differentiation

• Drive immunology research initiatives, including cellular assay development, immune cell function assays in vitro and in vivo to advance understanding of immune responses in autoimmune diseases

• High skills of animal handling, drug dosing and surgery of various tissues from disease models. Collaborate with team members to develop and validate the in vitro assays and in vivo animal disease models

• Conduct innovative in vitro experiments to explore cellular mechanisms and support drug discovery efforts, integrating findings from in vivo work to elucidate molecular mechanisms of action.

• Perform ex vivo assays to bridge the in vivo observations with molecular and cellular-level responses, providing insights into drug efficacy and mechanisms of action

• Comprehensive understanding of the functions of immune components contributing to the disease pathology in disease models. Translational relevance of research findings to human diseases and drug development strategies

• Apply expertise in therapeutic antibodies and nucleotide therapy to develop and validate novel treatment strategies in autoimmune disease models

• Experiences with humanized mouse model including PBMC engrafted and Human CD34+ hematopoietic stem cell-engrafted NSG mice is a plus

• Maintains SOP's and writes data summaries for experiments conducted

• Reviews, comprehends and complies with all SOP's, and safety and quality assurance standards

• Provides training and/or supervision to junior staff, as needed

• Other duties as assigned

• BS/BA degree in biology and 2+ years of relevant experience OR

• MS/MA degree in biology and some relevant industry experience preferred OR

• PhD or equivalent and Some relevant experience

• Demonstrated expertise in developing and characterizing autoimmune disease models, conducting immunology research, designing cellular assays, and utilizing therapeutic antibodies and nucleotide therapy

• Proficiency in laboratory techniques such as flow cytometry, cell culture, immune cell functional assays, and ex vivo assays.

• Strong analytical skills, with the ability to interpret complex data sets and derive meaningful insights.

• Knowledge and experience of in vivo pharmacokinetics and pharmacodynamics studies

• Extensive experience of handling animals and testing drug candidate as well as ex vivo assays of primary cells from the various disease models

• Knowledge and experience of immunology research and therapeutic Ab discovery

• Critical thinking of disease models and investigate drug candidate efficacy and capable of investigating the mechanism of action of drug candidates in vitro and in vivo

• Knowledge and experience in cellular signaling, phenotyping, differentiation and functionality analysis

• mAbs/bispecific Ab - understanding of antibody protein structure & function and assays applied for Ab discovery

• Ability to work as part of a team

• Excellent communication skills and the ability to collaborate effectively in a team-oriented environment

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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