Research Team Leader

The group develops and deploys improved targeting strategies for selective ablation of cell populations as well as engineering protein targets to facilitate small molecule screens. The work involves protein engineering, mammalian and bacterial expression, in vivo biology and application of automated strategies to the evaluation and modification of protein function. Work activities require an understanding of the requirements of Good Laboratory Practice and the conduct of studies to be submitted to health regulatory authorities.

The Research Team Leader I develops leads for preclinical toxicology and pharmacology testing and operates in compliance with applicable laws, regulations and guidances of competent health authorities of the appropriate jurisdiction. The Research Team Leader I understands the requirements of Good Laboratory Practice (GLP) as defined at 21 CFR part 58 and implements experimental designs consistent with GLP principles for studies intended to be submitted to regulatory authorities. The Research Team Leader I understands and complies with the quality management system of the regulated studies group.

The Research Team Leader I:

* Implements therapeutic candidate discovery programs

* Engages with the animal studies group/responsible veterinarian for design and execution of in vivo studies (rodents)

* Carries out data reduction and analysis, statistical inference and sensitivity testing

* Performs product design and feasibility testing

* Contributes to the development of quality technical agreements as needed

* Engage with CROs and manage outsourced activities 

Ph.D. degree required in molecular biology, biochemistry, immunology, biological or related sciences

* Superior organizational skills

* Ability to effectively manage staff

* Advanced degree of computer literacy

* Ability to make independent effective decisions

* Advanced research design and analytical skills.

* Advanced database statistical skills.

* In-depth knowledge of regulatory requirements 

* Excellent written and oral communication skills

* Highly motivated with a strong work ethic

Minimum of 5-7 years of experience required as a Research Specialist, Postdoctoral Fellow or Equivalent position.

Massachusetts General Hospital is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.