Senior Scientist - PKPD

We are seeking a team member who wants to be part of a diverse, world-class team transforming biomedical decision-making to improve health for all. We are obsessed with learning and we have a passion to participate in the growth of our scientific disciplines. We believe that as we learn, we have a responsibility to share openly with the community.

Our Mission: At Metrum Research Group, we are driven to improve health and defeat disease, particularly where there are unmet needs. We provide innovative solutions at the intersection of data, science, and technology to generate key insights that impact biomedical decision-making.

If you share our energy and priorities, we would love to hear from you!

MetrumRG is seeking a talented PKPD Modeling and Simulation Scientist with a minimum of 5 years of experience to join our team. We know that the key to our company’s success is the happiness and well-being of our team. Our goal is to provide a work-life that is engaging, rewarding, and fun.

Qualified individuals will contribute to fighting diseases through strategic collaborations with our clients in biomedical research, development, and post-marketing programs for new drugs, biologics, devices, and diagnostics. M&S scientists will be expected to develop and implement quantitative, data-driven pharmacometric strategies for knowledge integration and decision-making to guide drug development programs. Scientists will also contribute to internal and external reporting and publication of results and will be expected to continue to develop skills and knowledge in biomedical modeling and simulation.

Responsibilities

• Lead interactions with biomedical industry collaborators
• Develop strategies and conduct modeling and simulation to support biomedical decision making
• Develop population pharmacokinetic (PK), pharmacodynamic (PD), exposure-response, disease progression, and/or systems pharmacology models
• Apply models to support decision-making through Monte-Carlo simulation
• Perform model-based meta-analysis of therapeutic area summary-level data
• Perform quality control of modeling and simulation analyses
• Prepare technical reports, manuscripts, and presentations
• Work collaboratively within assigned agile project team(s) to accomplish team goals

Requirements and Skills

• Required: Strong proficiency with a scriptable modeling and simulation language (e.g. R, MatLab, Python)
• Required: Advanced expertise with domain-specific modeling software (e.g. NONMEM, ADAPT, Monolix) and Bayesian modeling software (e.g. Stan, JAGS, OpenBUGS)
• Desirable: Experience with Shiny, Markdown, LaTeX, unix/Linux, subversion, git
• Desirable: A strong understanding of statistical analysis of longitudinal, landmark, and repeated-measures, continuous or categorical data, within a multi-level hierarchy

Education and Experience

• Required: M.S. or Ph.D. Degree in Mathematics, Statistics, Pharmacometrics, Pharmacokinetics, Bioinformatics, Chemical or Biomedical Engineering, or related quantitative field
• Required: Minimum five years of experience in PKPD modeling and simulation post-graduate degree

Physical Demands:

The job frequently requires working at a computer terminal, standing or sitting, and the ability to operate a computer with proficiency.

Work Environment:

The work environment is quiet with no adverse conditions.

Metrum Research Group participates in E-verify.

Metrum Research Group offers competitive salaries and an excellent benefits package. You can read more about us by clicking the link at the top of this page, 'Company Website'.

Metrum Research Group EEO Statement

MetrumRG believes that innovation is cultivated when we challenge each other with new ideas and perspectives. MetrumRG is an equal opportunity employer that is committed to building a diverse and inclusive team. All employment decisions are based on qualifications, merit, and business needs, and we prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, gender identity, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

MetrumRG is committed to providing equal employment opportunities and reasonable accommodations for candidates and employees with disabilities. We encourage all qualified candidates to apply for positions within our organization. If you require reasonable accommodation because of a medical condition for the application or interview process, please contact Scotti Rylands or our Talent and Culture Department, (860)735-7043 x-622, or message us and we will work with you to meet your needs.